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Dr Kacper Rogala

Welcome to my personal website. My name is Dr Kacper Rogala and I am a scientist.

I work between two Cambridges: one in the USA and one in the UK, and am based at the Whitehead Institute / Massachusetts Institute of Technology (USA) and the MRC Laboratory of Molecular Biology (UK). I am also a College Research Associate at Sidney Sussex College, University of Cambridge, UK.

I am also a keen photographer and an experienced sailing skipper. Scroll down to learn more about my scientific background and interests.

Background

DPhil in Structural Biology, University of Oxford, UK
MRes in Molecular Biophysics, University College London, UK
BSc(Hons) in Biochemistry, University of Edinburgh, UK

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Research Interests

Being a professional scientist means that I do research for a living, and every day solve puzzles with the hope that one day my work will benefit thousands of people.

I am fascinated by how proteins work together in molecular assemblies. Since insights into such information are limited by the available technology, to understand how a large protein complex goes about to carry its function, I merge multiple structural biology techniques, and combine them with approaches from biochemistry, computational biology and cell biology. Such integrated research requires collaboration between many labs and people. We are working together to address basic science questions: how growth of organisms is regulated, and how its disregulation can lead to disease states?

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Publications

Palumbo V, Pellacani C, Heesom KJ, Rogala KB, Deane CM, Mottier-Pavie V, Gatti M, Bonaccorsi S, Wakefield JG. (2015) Current Biology, Misato controls mitotic microtubule generation by stabilizing the tubulin chaperone protein-1 complex.
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Rogala KB, Dynes NJ, Hatzopoulos GN, Yan J, Pong SK, Robinson CV, Deane CM, Gönczy P, Vakonakis I. (2015) eLife, The Caenorhabditis elegans protein SAS-5 forms large oligomeric assemblies critical for centriole formation.
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Bagnéris C, Rogala KB, Baratchian M, Zamfir V, Kunze MB, Dagless S, Pirker KF, Collins MK, Hall BA, Barrett TE, Kay CW. (2015) Journal of Biological Chemistry, Probing the Solution Structure of IκB Kinase (IKK) Subunit γ and Its Interaction with Kaposi Sarcoma-associated Herpes Virus Flice-interacting Protein and IKK Subunit β by EPR Spectroscopy.
pubmed, pdf

Hatzopoulos GN, Erat MC, Cutts E, Rogala KB, Slater LM, Stansfeld PJ, Vakonakis I. (2013) Structure, Structural analysis of the G-Box domain of the microcephaly protein CPAP suggests a role in centriole architecture.
pubmed, pdf

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